Excision biopsy demonstrated an eroded epidermis under which there were huge lobules of basaloid cells with central pigmentation .. HPV-Linked Throat Cancer Responds to Reduced Chemo, Radiation: Study: – THURSDAY, Oct. 22, 2015 – – Lower-level radiation and chemotherapy could be as effectual as standard doses for some patients with human papillomavirus -related tumor of the throat, tonsils and tongue, and may cause fewer unwanted effects, researchers say. The analysis included 43 patients who had favorable risk HPV-associated oropharyngeal cancer and were not heavy smokers. In comparison to standard treatment, their radiation therapy was reduced by 16 % and their chemotherapy dosage was reduced by 60 %.Alnylam Pharmaceuticals presents new data from its transthyretin-mediated amyloidosis program Alnylam Pharmaceuticals, Inc. Alnylam is developing ALN-TTR, a systemically delivered RNAi therapeutic targeting the TTR gene for the treating ATTR, including familial amyloidotic cardiomyopathy and familial amyloidotic polyneuropathy . There are a lot more than 100 mutations which have been determined in the TTR gene. ALN-TTR targets an area of the gene common to wild-type and all known mutant types of TTR, and consequently, has potential as a therapeutic for all individuals with FAC and FAP.D., Vice President, Research, CNS and Oncology at Alnylam.