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With the optical style method successfully demonstrated by Dubra’s team, even the tiniest cone cells at the guts of the retina, referred to as the foveal center, can be seen very clearly. Rods can be seen in a less central retinal location clearly. This is a really fascinating breakthrough, says Steve Burns, a professor in the educational school of Optometry at Indiana University, who’s not mixed up in Biomedical Optics Express research. Imaging contiguous rod mosaics allows us to review the influence of a complete new course of blinding disorders on the retina.Abdel-Rahman, Ph.D., Scott M. Stevens, M.D., Steven Yale, M.D., Emile R. Mohler, III, M.D., Margaret C. Fang, M.D., Vinay Shah, M.D., Richard B. Horenstein, M.D., Nita A. Limdi, Pharm.D., Ph.D., James A.S. Muldowney, III, M.D., Jaspal Gujral, M.B., B.S., Patrice Delafontaine, M.D., Robert J. Desnick, M.D., Ph.D., Thomas L. Ortel, M.D., Ph.D., Henny H. Billett, M.D., Robert C. Pendleton, M.D., Nancy L. Geller, Ph.D., Jonathan L. Halperin, M.D., Samuel Z. Goldhaber, M.D., Michael D. Caldwell, M.D., Ph.D., Robert M. Califf, M.D., and Jonas H. Ellenberg, Ph.D. For the COAG Investigators: A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing The need for clinical trials before widespread adoption of genotype-guided medication dosing and selection remains widely debated.1-4 Warfarin therapy has served as a model for the potential for pharmacogenetics to boost patient care.1 Observational studies have identified two genes, CYP2C9 and VKORC1, that are associated with variation in warfarin maintenance doses.